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KMID : 1022920230110010052
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Journal of Korean Academy of Social & Managed Care Pharmacy
2023 Volume.11 No. 1 p.52 ~ p.62
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Hypertension and Insulin Resistance from Prediabetes to Type 2 Diabetes: A 10-Years South Korean Prospective Cohort Study
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Jung Joo-Won
Cho Yoon
Lee Han-Kil
Han Eun-A
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Abstract
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BACKGROUNDS : There are many people with prediabetes. As prediabetes is a strong risk factor for Type 2 Diabetes and an opportunity to prevent Type 2 Diabetes, it is important to identify prediabetes with high risk of developing Type 2 Diabetes. The aim of this study is to examine whether hypertension or insulin resistance are valid transition factors
to Type 2 Diabetes from prediabetes.
METHODS : 2265 middle-aged South Korean examinees with prediabetes in the Korean Genome and Epidemiology Studies (KoGES) during the follow-up period of 10 years.
RESULTS : During 8.24 person-years, we identified 469 incident Type 2 Diabetes cases (21%). The incidence of Type 2 Diabetes increased with hypertension or insulin resistance with the adjusted hazard ratios (HRs) of 1.595 (CI: 1.209-2.105) and 2.286 (1.761-2.968) respectively. Compared to those with hypertension (Adjusted HR, 1.342 [CI: 1.045-1.723]), those with hypertension and insulin resistance showed a larger HR (Adjusted HR, 2.593 [CI: 1.802-3.733]).
CONCLUSION : Middle-aged South Koreans with prediabetes who had hypertension or insulin resistance were especially high at risk of developing Type 2 Diabetes. Hypertension had an association wi
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KEYWORD
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Prediabetes, Type 2 Diabetes, Hypertension, Insulin resistance, Korean Genome and Epidemiology Studies
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